实验研究PI3K/Akt抑制剂联合顺铂治疗肺癌(3)

来源:南粤论文中心 作者:吴秋歌 王静 蒋军广 发表于:2010-01-10 23:14  点击:
【关健词】肺肿瘤;凋亡;PI3K;LY294002;顺铂
2 Brognard J,Clark AS,Ni Y,et al.Akt/protein kinase B is constitutively active in nonsmall cell lung cancer cells and promotes cellular survival and resistance to chemotherapy and radiation〔J〕.


  2 Brognard J,Clark AS,Ni Y,et al.Akt/protein kinase B is constitutively active in nonsmall cell lung cancer cells and promotes cellular survival and resistance to chemotherapy and radiation〔J〕.Cancer Res,2001;61(10):398697.

  3 段庚仙.非小细胞肺癌治疗现状〔J〕.肿瘤研究与临床,2003;15(4):75678.

  4 Han JY,Chung YJ,Park SW,et al.The relationship between cisplatininduced apoptosis and p53,bcl2 and bax expression in human lung cancer cells〔J〕.Korean J Intern Med,1999;14(1):4252.

  5 汤钊猷.现代肿瘤学〔M〕.第2版.上海:上海医科大学出版社,2000:461.

  6 Fulda S.Targeting inhibitor of apoptosis proteins(IAPs) for cancer therapy〔J〕.Anticancer Agents Med Chem,2008;8(5):5339.

  7 Hannigan GE,Dedhar S.Protein kinase mediators of integrin signal transduction〔J〕.J Mol Med,1997;75(1):3544.

  8 Alexia C,Bras M,Fallot G,et al.Pleiotropic effects of PI3′ kinase/Akt signaling in human hepatoma cell proliferation and druginduced apoptosis〔J〕.Ann N Y Acad Sci,2006;1090:117.

  9 Poh TW,Pervaiz S.LY294002 and LY303511 sensitize tumor cells to druginduced apoptosis via intracellular hydrogen peroxide production independent of the phosphoinositide 3kinaseAkt pathway〔J〕.Cancer Res,2005;65(14):626474.

  10 Page C,Lin HJ,Jin Y,et al.Overexpression of Akt/Akt can modulate chemotherapyinduced apoptosis〔J〕.Anticancer Res,2000;20(1):40716.

  11 Gerber HP,Mc Murtrey A,Kowalski J,et al.Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3′kinase/Akt signal transduction pathway requirement for FIK1/KDR activation〔J〕.J Biol Chem,1998;273(46):3033643.

  12 Howells LM,Hudson EA,Manson MM.Inhibition of phosphatidylinositol 3kinase/protein kinase B signaling is not sufficient to account for indole3carbinolinduced apoptosis in some breast and prostate tumor cells〔J〕.Clin Cancer Res,2005;11(23):85217.
 

(责任编辑:南粤论文中心)转贴于南粤论文中心: http://www.nylw.net(南粤论文中心__代写代发论文_毕业论文带写_广州职称论文代发_广州论文网)
顶一下
(0)
0%
踩一下
(0)
0%


版权声明:因本文均来自于网络,如果有版权方面侵犯,请及时联系本站删除.